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Drugs that interfere with serotonin reuptake inhibitionincluding ZOLOFTincrease the risk of bleeding eventsConcomitant use of aspirinnonsteroidal anti-inflammatory drugsNSAIDsother antiplatelet drugswarfarinand other anticoagulants may add to this riskCase reports and epidemiological studiescase-control and cohort designhave demonstrated an association between use of drugs that interfere with serotonin reuptake and the occurrence of gastrointestinal bleedingBleeding events related to drugs that interfere with serotonin reuptake have ranged from ecchymosishematomaepistaxisand petechiae to life-threatening hemorrhages.
Are there potential interaction issues for people taking Zoloft and any other drugs?
In 354 geriatric subjects treated with ZOLOFT in MDD placebo-controlled trialsthe overall profile of adverse reactions was generally similar to that shown in Table 3[See ADVERSE REACTIONSexcept for tinnitusarthralgia with an incidence of at least 2and at a rate greater than placebo in geriatric patients.
False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking ZOLOFTThis finding is due to lack of specificity of the screening testsFalse-positive test results may be expected for several days following discontinuation of ZOLOFTConfirmatory testssuch as gas chromatography/mass spectrometrywill help distinguish ZOLOFT from benzodiazepinesSee DRUG INTERACTIONS
Inform patients about the concomitant use of ZOLOFT with aspirinNSAIDsother antiplatelet drugswarfarinor other anticoagulants because the combined use has been associated with an increased risk of bleedingAdvise patients to inform their health care providers if they are taking or planning to take any prescription or over-thecounter medications that increase the risk of bleedingSee WARNINGS AND PRECAUTIONS
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common side effects of zoloft include dry mouth, insomnia, and nausea.