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The cholesterol content of the liver is derived predominantly from three sourcesThe liver can synthesize cholesteroltake up cholesterol from the blood from circulating lipoproteinsor take up cholesterol absorbed by the small intestineIntestinal cholesterol is derived primarily from cholesterol secreted in the bile and from dietary cholesterol.
You should not use Zetia if you have moderate to severe liver diseaseYou should not use ezetimibe with astatincholesterol medicine if you have active liver diseaseor if you are pregnant or breast-feeding a baby.
This drug may increase the risk of liver damagewhen taken with astatinor muscle damage when taken with a fibrate orstatinTell your doctor right away if you experience any of the following symptomssigns of liver problemssuch as severe stomach/abdominal painpersistent nausea/vomitingyellowing eyes/skindark urinemuscle pain/tenderness/weaknessespecially with fever or unusual tiredness
It is not known whether ezetimibe is excreted into human breast milkIn rat studiesexposure to total ezetimibe in nursing pups was up to half of that observed in maternal plasmaBecause many drugs are excreted in human milkcaution should be exercised when ZETIA is administered to a nursing womanZETIA should not be used in nursing mothers unless the potential benefit justifies the potential risk to the infant.
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