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The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytesAfter discontinuation of latanoprostpigmentation of the iris is likely to be permanentwhile pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patientsPatients who receive treatment should be informed of the possibility of increased pigmentationBeyond 5 years the effects of increased pigmentation are not knownsee Clinical Studies
The usual dose is one drop into the affected eye or eyes once daily in the eveningThe hands should be washed before each use of latanoprost or any eye medicationContact lenses should be removedThe head is tilted back and the lower eyelid is pulled down with the index finger to form a pouchIt is important not to touch the tip of the dropper to the eye or the eyelid so that bacteria are not introduced into the bottleThe bottle is squeezed slightly to allow the prescribed number of drops into the pouchThe eye is closed gently for 2 to 3 minutes without blinking.
Rednessswellingitchingor pain in or around your eyeoozing or discharge from your eyeincreased sensitivity to lightvision changesor chest pain.
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